Codeine continues to be identified as an endogenous compound, coupled with morphine, during the brains of nonhuman primates with depolarized neurons, indicating that codeine may well function as being a neurotransmitter or neuromodulator from the central nervous procedure.
Substances With this routine Possess a reduced prospective for abuse relative to substances mentioned in Schedule IV and consist principally of preparations that contains confined portions of certain narcotics.
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Binding of codeine or morphine to the mu opioid receptor ends in hyperpolarization of the neuron resulting in the inhibition of release of nociceptive neurotransmitters, causing an analgesic result and increased pain tolerance resulting from minimized neuronal excitability.[35][36]
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